chimeric antigen receptor

Multiple myeloma is a cancer of the plasma cells. Carvykti, a CAR T therapy by Johnson & Johnson and ... Legend Biotech, targets an antigen called BCMA found on the plasma cell surface and yields promising clinical results. Legend…

Image of red blood cells and abnormal white blood cells in an acute lymphocytic leukemia cell blood ... smear, analyzed by microscope at 1000x magnification. getty As part of our series in cellular therapy, we previously described how CAR…

Conceptual image of a multiple sclerosis neuron.getty Here we describe the use of CAR T therapy to treat multiple sclerosis in mice. Previous installments discuss the fundamentals of CAR T and its applications for B cell cancers, multiple…

Digital xrays of both hands showing severe rheumatoid arthritis affecting both wrists and hands. ... Deformities limiting movement and associated with pain.getty Here we describe the use of CAR T therapy to treat mice with experimental…

Tumor cell, CAR-T cell, treatment by immunotherapy with gene encoding CAR. This illustration shows a ... cancerous tumor in the lower right. T cells are shown on the left side of the illustration. These lymphocytes are modified with the…

CRISPR technology has advanced the field of genetic engineering, and could soon profoundly impact ... the world of CAR T therapy. getty Here we describe the integration of CRISPR gene-editing technology to improve CAR T therapy design.…

Malignant cell destroyed by engineered T cells with wrecking ball forcegetty This is a series on the advances in CAR T, a remarkable immunotherapy treatment dubbed a “living drug.” This first installment will lay the foundation for…