TV tonight: people are milking toads for their psychedelic venom

Would you milk a toad for its hallucinogenic goods? In Mexico, there is a craze for people inhaling the Sonoran desert toad’s 5-MeO-DMT, an element (illegal in the US and UK) that is reported to help with depression and addiction but with possible side-effects including anxiety and psychosis. From the drug-trafficking “red zone” of Sonora, journalist Guillermo Galdos investigates and meets the controversial doctor and so-called “godfather” of the practice and a psychiatrist conducting a clinical trial on it. Hollie Richardson

Gardeners’ World Winter Specials

8pm, BBC Two

Snowdrops, dogwood “midwinter fire”, hellebores and even daffodils (which can flower as early as December) are just some of the flora that Rachel de Thame marvels at on a visit to Anglesey Abbey’s garden. Later, prickly enthusiast Eric Saunders shows off his collection of 1,000 cacti and succulents. HR

Kirstie’s Handmade Christmas

8pm, Channel 4

A cadre of expert makers join Kirstie Allsopp at her alpine getaway to create festive treats, from pasta crackers to odd-sock snowmen. It’s all very hygge on the surface, but there is a definite gleam in Allsopp’s eye as she wields a rapid-fire tufting machine, a chainsaw and a flame gun. Graeme Virtue

The Great Game

9pm, Sky Atlantic

The lurid Italian football-agent drama roars soapily to a climax with a final double bill. Several alliances have already surprisingly flipped but there are more curveballs to come, as Corso (Francesco Montanari) tries to cement big plans for both the agency and his star player. Expect plenty of spilt prosecco. Jack Seale

The Graham Norton Show

10.55pm, BBC One

It’s a double whammy of Kate Winslet on your box this week, who’s here to promote the upcoming Avatar sequel. Joining her is a lovely medley of Lenny Henry, Nadiya Hussain and Jack Whitehall. Oh, and Olly Murs. HR

The Big Narstie Show

11.05pm, Channel 4

What will Gogglebox supremo Scarlett Moffatt, motormouth promoter Eddie Hearn, creativity machine Kojey Radical and long multiplication champion Carol Vorderman find to talk about when they are thrown together? Big Narstie and Mo Gilligan’s genre-defying chatshow guarantees there won’t be a dull moment. Hannah Verdier

Live sport

Rugby Union: Heineken Champions Cup – London Irish v Montpellier, 7.15pm, BT Sports 1 The opening match from the Gtech Community Stadium.